间变性大细胞淋巴瘤的p80蛋白表达及其临床意义

目的 研究染色体易位ｔ（２;５）所形成的嵌合基因ＮＰＭ－ＡＬＫ的蛋白产物－－Ｐ８０蛋白在间变性大细胞淋巴瘤（ＡＬＣＬ）中的表达及与其亚型和预后的关系。方法 对已进行临床、病理和免疫学分析胼有随访资料的１９例ＡＬＣＬ用免疫组织化学ＡＢＣ法标记Ｐ８０蛋白。结果 Ｐ８０蛋白在１９例中有９例呈强阳性,组织学亚型为普通型和小细胞型,无１例为霍金样型（Ｐ〈０．０５）。Ｐ８０蛋白阳性病例的免疫学表型为Ｔ细胞性产

The expression and clinical significance of p80 protein in anaplastic large cell lymphoma

Objective To investigate the relationship of expression of NPMALK cohesive gene protein with the subtypes and prognosis of anaplastic large cell lymphoma (ALCL). Methods Nineteen cases of ALCL with CD30 positivity were studied. Immunohistochemical staining was performed in paraffin sections by using polyclonal antibody antip80 and other monoclonal antibodies. The clinical data of these patients were analyzed and all patients were followedup. Results The neoplastic cells in 9 out of 19 ALCL expressed p80 protein. Histopathologically, all 9 cases with p80 expression were common type and small cell type. None of these 9 cases were Hodgkin like type (P<0.05). Immunologically, all the 9 positive cases were T and null cell phenotype and none of them was B cell or other phenotype (P<0.05).Clinically, the patients with p80 expression were younger than those without p80 expression (P<0.05). The prognosis of the former was worse than in the later (P<0.05). Conclusions p80 positive ALCL could be a new clinicopathological entity. The polyclonal antibody antip80 might be an useful marker for the differential diagnosis and prognosis estimation of ALCL.