EV71-IgM抗体阳性的手足口病患儿免疫球蛋白血糖和脑脊液检测结果分析

目的分析肠道病毒71型(enterovirus 71,EV71)抗体阳性的手足口病患儿免疫球蛋白、血糖、脑脊液的检测结果,探讨其临床意义。方法选取胶体金法检测EV71-IgM阳性、阴性的手足口病患儿各50例,行血清免疫球蛋白、血糖及脑脊液检查,采用SPSS 12.5软件统计分析2组病例各项实验指标的差异。结果 50例EV71抗体阳性组患儿血清免疫球蛋白IgA、IgG、IgM分别为(0.52±0.38)、(8.36±2.15)和(1.52±0.26)g/L,50例EV71抗体阴性组患儿血清免疫球蛋白IgA、IgG、IgM分别为(0.41±0.21)、(8.45±2.34)和(1.48±0.27)g/L,2组比较,差异无统计学意义(P0.05)。50例EV71抗体阳性患儿中有26例血糖升高,血糖升高率为52.0%;22例脑脊液检查异常,脑脊液检查异常率为44.0%。而50例EV71抗体阴性组患儿中有4例血糖升高,血糖升高率为8.0%;3例脑脊液检查异常,脑脊液检查异常率为6.0%。2组比较,差异均有统计学意义(均P0.05)。结论在手足口病患儿中开展EV71抗体的检测同时检测患儿血糖和脑脊液有助于危重患儿的早期诊断和治疗。

Testing results of immunoglobulin,blood glucose and cerebrospinal fluid of children with hand-foot-mouth disease of EV71-IgM positive

[Objective]To analyze the testing results of immunoglobulin,blood glucose and cerebrospinal fluid of children with hand-foot-mouth disease(HFMD)and EV71-IgM positive,and explore its clinical significance.[Methods]EV71-IgM was detected by colloidal gold method on 50 children with HFMD of EV71-IgM positive and 50 cases of antibody negative.Levels of serum immunoglobulin,blood glucose and cerebrospinal fluids were detected.The difference of testing results in 2 groups were analyzed by SPSS 12.5.[Results] The levels of IgA,IgG and IgM in the group of EV71 antibody positive were(0.52±0.38) g/L,(8.36±2.15) g/L and(1.52±0.26) g/L respectively.Those in the group of EV71 antibody negative were(0.41±0.21) g/L,(8.45±2.34) g/L and(1.48±0.27) g/L respectively.There were no significant differences between 2 groups(P>0.05).There were 26 cases of blood glucose elevation(52%) and 22 cases of abnormal cerebrospinal fluid(44%) in the group of EV71 antibody positive.While,there were 4 cases of blood glucose elevation(8%) and 3 cases of abnormal cerebrospinal fluid(6%)in the group of EV71 antibody negative,the differences between 2 groups were significant(P<0.05).[Conclusion]The EV71-IgM detection combined with glucose and cerebrospinal fluid detection contributes to the early diagnosis and treatment of critically diseased children.