老年冠心病合并代谢综合征患者平均血小板体积的相关性研究

目的研究合并代谢综合征(MS)老年冠心病患者的平均血小板体积(MPV)变化及相关影响因素。方法选择冠状动脉造影确诊的老年冠心病患者288例,根据诊断分为MS组154例和非MS组134例。测定入院时MPV、脂联素、高敏C反应蛋白(hs-CRP)等指标,并进行相关性分析。结果与非MS组比较,MS组MPV和血小板分布宽度显著升高,差异有统计学意义(P<0.05,P<0.01);相关性分析显示,MS组患者MPV与体质量指数、空腹胰岛素、胰岛素抵抗指数(HOMA-RI)、hs-CRP和冠状动脉病变积分呈正相关(P<0.05,P<0.01),与HDL-C和脂联素呈负相关(P<0.01);多重线性回归分析显示,MS组MPV与hs-CRP、HOMA-RI显著独立正相关,与脂联素和HDL-C显著独立负相关(P<0.05)。结论合并MS的老年冠心病患者MPV显著升高,与hs-CRP、HOMA-RI、脂联素及HDL-C有密切关系。

Mean platelet volume in elderly coronary heart disease patients with metabolic syndrome

Objective To study the mean platelet volume(MPV)in elderly coronary heat disease(CHD)patients with metabolic syndrome(MS)and its related factors.Methods Two huddred and eighty-eight coronary angiography-established CHD patients were divided into MS group(n= 154)and non-MS group(n=134).Their MPV,serum adiponectin and hs-CRP level,and Gensini score were measured at admission.Results The MPV and platelet distribution width were significantly higher in MS group than in non-MS group(P<0.05,P<0.01).The MPV was positively correlated with the BMI,serum fasting insulin level,insulin resistance index,hs-CRP and Gensini score(P<0.05,P<0.01)and negatively with the serum HDL-C and adiponecin level(P< 0.01).Multivariate linear regression analysis revealed that hs-CRP and insulin resistance index were the positive independent risk factors for MPV whereas the serum HDL-C and adiponectin level were the negative independent risk factors for MPV(P<0.05).Conclusion The MPV is significantly higher in elderly CHD patients with MS,which is closely related with the serum levels of hs-CRP,adiponectin and HDL-C.