糖尿病患者非高密度脂蛋白胆固醇和载脂蛋白A-Ⅰ比值与冠状动脉病变程度的相关性

目的探讨非HDL-C(NHDL-C)/载脂蛋白A-Ⅰ(apoA-Ⅰ)比值与2型糖尿病患者冠状动脉病变严重程度的相关性。方法选择因劳力性胸痛而行冠状动脉造影的2型糖尿病患者373例,依据Gensini评分三分位分为3组,低分组<8分(143例);中分组8²8分(109例);高分组>28分(121例),评价NHDL-C/apoA-Ⅰ比值与冠状动脉病变严重程度的相关性。结果 3组患者HDL-C、脂蛋白(a)、apoB、NHDL-C、NHDL-C/apoA-Ⅰ比值等比较,差异有统计学意义(P<0.05,P<0.01);Pearson相关分析和Spearman相关分析均显示,2型糖尿病患者NHDL-C/apo-A-Ⅰ比值与Gensini评分呈正相关(r=0.146,P<0.01;r=0.127,P<0.05)。多元线性回归分析显示,2型糖尿病患者NHDL-C/apoA-Ⅰ比值与冠状动脉病变严重程度独立相关(偏相关回归系数=3.361,P<0.05)。结论 NHDL-C/apoA-Ⅰ与2型糖尿病患者冠状动脉病变严重程度独立相关。

Correlation between NHDL-C/apoA-Ⅰratio and severity of coronary artery disease in type 2 diabetic patients

Objective To study the correlation between NHDL-C/apoA-Ⅰ ratio and severity of coronary artery disease in type 2diabetic patients.Methods Three hundred and seventy-three type 2diabetic patients who underwent coronary angiography were divided into low Gensini score group(n=143),intermediate Gensini score group(n=109),and high Gensini score group(n= 121).The correlation between NHDL-C/apoA-Ⅰratio and severity of coronary artery disease was assessed.Results The serum levels of HDL-C,lipoprotein(a),apoB,NHDL-C,NHDL-C/apoA-Ⅰ were significantly different in the 3groups(P<0.05,P<0.01).Pearson and Spearman correlation analysis showed that the NHDL-C/apoA-Ⅰ ratio was correlated with the Gensini score in type 2diabetic patients(r=0.146,P<0.01;r=0.127,P<0.05).Multivariate linear regression analysis displayed that the NHDL-C/apoA-Ⅰratio was independently correlated with the severity of coronary artery disease in type 2diabetic patients(partial correlation regression coefficient= 3.361,P<0.05).Conclusion The NHDL-C/apoA-Ⅰratio is independently correlated with the severity of coronary artery disease in type 2diabetic patients.