Elevated anti-alginate serum titers in patients with acute cholangitis and gallstones imbedded withPseudomonas aeruginosa |
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| Authors: | Yushi Uetera Keiichi Hiramatsu Takeshi Yokota Katsuhiro Sato Masatoshi Ogawa |
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| Affiliation: | (1) Second Department of Surgery, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, 113 Tokyo, Japan;(2) Department of Bacteriology, Juntendo University, Tokyo, Japan;(3) Juntendo Medical College of Nursing, Tokyo, Japan;(4) Division of Electron Microscopy, Juntendo University, Tokyo, Japan;(5) Manager, Bacteriology Laboratory, New Product Development Center, Pfizer Pharmaceuticals Inc., Tokyo, Japan |
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| Abstract: | Electron microscopy and bacteriological culture revealed viable bacteria covered with a glycocalyx (biofilm) in choledochal stones recovered from two patients with acute cholangitis. On the cut surface of the choledochal stones, the cholesterol stone component was surrounded with a layer of brown pigment stone. In each case, bacterial culture of the choledochal stone recoveredPseudomonas aeruginosa. Since alginate is the main component of the glycocalyx produced byP. aeruginosa, serum IgM, IgG and IgA anti-alginate antibodies were measured in each patient. The present study is the first to demonstrate acute and transient IgM seroconversion to alginate in cases of acute cholangitis. In one case, the elevation of anti-alginate IgM preceded the elevation of anti-alginate IgG. The authors propose that the bacterial glycocalyx may play a significant role in acute cholangitis. |
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| Keywords: | cholangitis bacterial glycocalyx biofilm brown pigment stone anti-alginate IgM antibody Pseudomonas aeruginosa |
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