氪激光低能量光凝治疗年龄相关性黄斑变性合并脉络膜新生血管患者的临床效果

目的 探讨氪激光低能量光凝治疗年龄相关性黄斑变性(AMD)合并脉络膜新生血管(CNV)患者的疗效。方法 湿性AMD患者17例(17只眼),经荧光素眼底血管造影(FFA)或吲哚氰绿血管造影(ICGA)检测,确诊为黄斑中心凹下CNV。患者年龄50—74岁,平均61岁。在黄斑病变区相应视野中心暗点内,应用氪激光行低能量光凝治疗。术后4周CNV仍有活动者再次行光凝治疗。每例患者治疗前和复诊时均检查视力、眼前节、眼底及视野,并行眼底照相和FFA、ICGA检测。患者术后定期随访1-8年,平均3．5年。结果 术后所有患者的治疗眼均未出现即刻视力下降现象,局部出血和渗出明显消退。FFA检测证实CNV关闭或缩小,渗漏减少,其中9例患者随诊3年以上未见复发。术后6只眼视力增进,8只眼视力不变,3只眼视力减退。视野复查见中心暗点无明显变化。结论应用氪激光低能量光凝治疗AMD合并黄斑中心凹下CNV患者具有疗效好、复发者少等优点。(中华眼科杂志,2004,40：808-811）

Krypton laser photocoagulation at low power setting for age-related macular degeneration complicated with subfoveal choroidal neovascularization

OBJECTIVE: To evaluate the efficacy of krypton laser photocoagulation for treatment of age-related macular degeneration (AMD) complicated with mainly subfoveal classic choroidal neovascularization (CNV). METHODS: Seventeen eyes of 17 cases, aged 50 - 74 years (averaged 60.8 years) with mainly subfoveal classic choroidal neovascularization were treated with krypton laser at lower power setting. The treatment was completed in one session. Another course of treatment was given 4 weeks later if there was active leakage demonstrated at the CNV area. Visual acuity, anterior segment and fundus examination, perimetry test, fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed before and after treatment. The follow-up period was 3.5 years on average (1 - 8 years). RESULTS: There was no immediately decrease of visual acuity after treatment. All treated eyes showed absorption of hemorrhages and/or exudates and diminished leakages. Visual acuity was stable in 8 eyes; improved in 6 eyes (>/= 2 lines), and decreased in 3 eyes (