吡柔比星膀胱灌注预防膀胱癌术后复发临床观察

目的:分析2002年6月~2005年8月间158例浅表性膀胱癌患者行膀胱部分切除术或行TUR-Bt术后采用吡柔比星(THP)膀胱灌注预防肿瘤复发。方法:THP30mg,每周1次,连用8周,而后每月1次,连用10个月,总疗程12个月。结果:所有患者均获6~24个月的随访。平均随访12.3个月。复发20例,复发率12.8%。结论:THP用于膀胱灌注预防膀胱癌术后复发有较好的疗效,不良反应少,给药方便,值得临床推广应用。

Clinical study on intravesical instillation of pirarubicin(THP) for prevention of postoperative recurrence of bladder cancer

Objective:To investigate the effects of intravesical instillation of pirarubicin(THP) to prevent postoperative recurrence of superficial bladder cancer after partial cystectomy or transurethral resection(TUR-Bt). Methods: Intravesical instillation of 30mg of THP dissolved in 50ml normal saline and retained in bladder for 30 minutes was given to the patients once a week for 8 weeks and subsequently once a month for ten months. Results: The mean follow up time was 12.3 months and the tumor recurrence rate was 12.8%. Conclusion: Intravesical instillation of THP is effective for prevention of postoperative recurrence of superficial bladder cancer with less side effect and easy to use so it can be widely used in such patients.