Seroprevalence of pertussis among healthcare workers: A cross-sectional study from Tunisia |
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Authors: | Ikram Ben Fraj Hanen Smaoui Maroua Zghal Orjouane Sassi Nicole Guiso Amel Kechrid |
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Affiliation: | 1. University of Tunis El Manar, Children’s Hospital of Tunis, Laboratory of Microbiology, UR12ES01, Beb Saadoun, 1007 Tunis, Tunisia;2. Occupational Medicine Department, Children’s Hospital of Tunis, Beb Saadoun, 1007 Tunis, Tunisia;3. Institut Pasteur, Unité de prévention et thérapies moléculaires des maladies humaines, 25–28, rue du Docteur-Roux, 75724 Paris cedex 15, France |
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Abstract: | This cross-sectional study aimed to assess pertussis seroprevalence among healthy healthcare workers (HCW) of the Children’s Hospital of Tunis, Tunisia. During the study period, 236 blood samples were obtained to determine HCW exposure to pertussis. Concentrations of immunoglobulin G (IgG) to pertussis toxin (PT) were measured using a commercial enzyme-linked immunosorbent assay. Cut-offs values used were 40 and 100?IU/ml, respectively indicative of an infection within the last year and a current/recent infection. Overall, seropositivity rate was 11.4% (95% CI 7.4–15.5) and 2.5% (95% CI 0.5–4.6) of ELISA results were indicative of a current infection. Seroprevalence was significantly most important in nurses (p?=?0.03) and in participants aged 21–31y (p?=?0.009). Our study confirmed that pertussis is circulating in hospital settings and affecting Tunisian HCW, in close contact with infants. Therefore, a booster dose of acellular pertussis vaccine needs to be considered. |
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Keywords: | Pertussis toxin Bordetella Seroprevalence Healthcare workers |
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