Contrast-enhanced color Doppler ultrasound characteristics in hypervascular breast tumors: comparison with MRI |
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Authors: | L Alamo U Fischer |
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Institution: | Department of Radiology, Georg-August-Universit?t, Robert-Koch-Strasse 40, 37075 G?ttingen, Germany e-mail: l.alamo@med.uni.goettingen.de Tel.: + 49-5 51-39 89 65 Fax: + 49-5 51-39 96 06, DE
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Abstract: | The aim of this study was to evaluate the accuracy of contrast-enhanced color Doppler ultrasound (CE-US) in comparison with
contrast-enhanced MR imaging (CE-MRI) in the discrimination of hypervascularized breast tumors. An additional CE-US of the
breast was preoperatively performed in 40 patients with a hypervascular breast lesion detected on CE-MRI. The presence of
blood flow signals and the morphological characteristics of the vessels in the breast lesions were evaluated pre- and post-contrast
administration, as well as the dynamic aspects of the Doppler signal, including time interval to maximum signal enhancement
and persistence of the signal enhancement. Twenty-three carcinomas and 17 fibroadenomas were explored. Considering initial
signal enhancement > 100 % after the administration of contrast material as a criterion suggesting malignancy, CE-MRI showed
a sensitivity of 100 % and a specificity of 76.5 % in the detection of malignant breast tumors. Color Doppler signals were
consistently demonstrated in all carcinomas and in 68.7 % of fibroadenomas after the administration of Levovist, with CE-US
showing a sensitivity of 95.6 % and a specificity of 5.9 %. Neither the mean number of vessels per tumor, nor the location
of vessels, the time to maximum increase of the Doppler signal or the persistence of signal enhancement showed significant
differences between benign and malignant lesions. Additional CE-US does not increase the low specificity of MRI in patients
with hypervascularized breast tumors.
Received: 17 July 2000 Revised: 22 August 2000 Accepted: 24 August 2000 |
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Keywords: | Breast tumors Doppler ultrasound MRI Contrast material |
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