n-Butyl Acrylate: Prenatal Inhalation Toxicity in the Rat

n-Butyl Acrylate: Prenatal Inhalation Toxicity in the Rat. Merkle,J. and Klimisch, H.-J. (1983). Fundam. Appl. Toxicol. 3:443–447.n-Butyl acrylate was examined for its prenatal toxicity in Sprague-Dawleyrats. Inseminated rats were exposed to concentrations of 0,25, 135 and 250 ppm for a duration of 6 hours per day from the6th to 15th day post coitum. Subsequently the animals were heldto the 20th day post coitum. During the inhalation period concentrationsof 135 and 250 ppm n-butyl acrylate led to maternal toxicity(delayed body weight gain depending on the concentration, clinicalsigns of irritation). At the end of the exposure period thesigns subsided. The same concentrations induced embryo-lethality(increased number of dead implantations depending on the concentration).25 ppm of n-butyl acrylate did not lead to maternal toxicityor embryolethality. Under the conditions chosen, a teratogeniceffect of the test substance was not detected at any concentration.