Lowering serum uric acid to prevent acute kidney injury |
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| Authors: | Ejaz A Ahsan Dass Bhagwan Kambhampati Ganesh Ejaz Noel I Maroz Natallia Dhatt Gurjit S Arif Amir A Faldu Chirag Lanaspa Miguel A Shah Gaurav Johnson Richard J |
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| Affiliation: | Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA. ejazaa@medicine.ufl.edu |
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| Abstract: | Epidemiological, experimental and clinical studies support a role for uric acid in acute kidney injury (AKI). We discuss how the conventional role of uric acid in AKI has now evolved from intratubular crystal deposition to pro-inflammatory, anti-angiogenic and immunological function. Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways. |
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