| 青藤碱干预多柔比星肾病大鼠的实验研究 |
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| 引用本文： | 王丽敏,王丽娜,李春玉,邹艳红,王海燕.青藤碱干预多柔比星肾病大鼠的实验研究[J].黑龙江医药科学,2011,34(5):5-6. |
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| 作者姓名： | 王丽敏 王丽娜 李春玉 邹艳红 王海燕 |
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| 作者单位： | 佳木斯大学附属第一医院儿科,黑龙江佳木斯,154003 |
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| 基金项目： | 黑龙江省中医管理局科研项目,编号:ZHY10-W66 |
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| 摘 要： | 目的:观察白介素-6(IL-6)在多柔比星肾病大鼠肾组织及尿液中的表达及青藤碱(SIN)对其表达的影响.方法:雄性Wistar大鼠120只.随机分为正常组32只,肾病组88只.肾病组大鼠单次尾静脉注射多柔比星5mg/kg,制备微小病变型肾病(MCNS)模型.采用酶联免疫吸附法(ELISA)检测各组大鼠不同时期肾组织及尿...
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| 关 键 词： | 多柔比星肾病 白细胞介素-6 蛋白尿 大鼠 青藤碱 |
Effects of sinomenine on doxorubicin nephropathic rats: An experimental study |
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| WANG Li-min,WANG Li-na,LI Chun-yu,ZOU Yan-hong,WANG Hai-yan.Effects of sinomenine on doxorubicin nephropathic rats: An experimental study[J].Heilongjiang Medicine and Pharmacy,2011,34(5):5-6. |
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| Authors: | WANG Li-min WANG Li-na LI Chun-yu ZOU Yan-hong WANG Hai-yan |
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| Institution: | WANG Li-min,WANG Li-na,LI Chun-yu,ZOU Yan-hong,WANG Hai-yan(The First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China) |
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| Abstract: | Objective:To observe the interleukin-6(IL-6) expression in the renal tissue and urine of doxorubicin nephropathy rats and the effect of Sinomenine(SIN) on its expression.Methods: We divided 120 male Wistar rats randomly into normal group(32) and nephropathy group(88).A single intravenous injection of doxorubicin 5mg/kg was given to nephritic rats to prepare with nephropathy(MCNS) model.We used enzyme-linked immunosorbent assay(ELISA) to detect the IL-6 expression in the different periods of the renal tissue... |
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| Keywords: | doxorubicin nephropathy interleukin-6 proteinuria rats sinomenine |
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