麝香配伍冰片对局灶性脑缺血再灌注大鼠行为学及脑梗死体积的影响

目的研究麝香配伍冰片对局灶性脑缺血再灌注大鼠行为学及脑梗死体积的影响。方法用大脑中动脉线栓法建立大鼠局灶性脑缺血再灌注模型，检测脑梗死体积，并比较其神经功能行为积分。结果脑缺血2h再灌注24h，模型组脑梗死体积显著增大，与假手术组比较有统计学意义（P〈0．01），神经功能行为积分显著升高（P〈0．01）；麝香配伍冰片组脑梗死体积较模型组缩小（P〈0．01），同时，麝香冰片组、麝香组大鼠神经功能行为积分下降（P〈0．05）。其中以麝香配伍冰片组作用最明显。结论麝香配伍冰片可减少局灶性脑缺血再灌注大鼠脑梗死体积，改善脑缺血后神经行为症状。

The Influence of Musk with Borneol on the Cerebral Infarction Area and Neural Function in Rats with Focal Cerebral Ischemia/Reperfusion

Objective To investigate the effect of musk with borneol on the volume of cerebral infarction and the Neural function in rats with cerebral focal ischemia with reperfusion.Methods The models of MCAO-reperfusion was induced by the method of nylon monofilament via the internal carotid artery. Technique of image analysis was used to calculate the volume of cerebral infarction and scores of neural function were evaluated.Results After cerebral ischemia for 2 hours and reperfusion for 24 hours,the volume of cerebral infarction in the model group increased significantly(P<0.01), the scores of the neural function increased(P<0.01).The volume of cerebral infarction in musk with borneol group was significantly lower than that in the model group(P<0.05).The scores of the neural function in musk with borneol group,musk group were significantly lower than that in the model group(P<0.05) and (P<0.01).Conclusion Musk with borneol could decrease the volume of cerebral infarction and improve the Neural function after focal cerebral ischemia with reperfusion.