Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern |
| |
Authors: | R Schröder Reinhold P Linke |
| |
Institution: | Institut für Pathologie, Neuropathologie, Universit?t K?ln, Joseph-Stelzmann-Strasse 9, D-50924 Cologne, Germany Fax: +49-221-478-6360, DE Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany, DE
|
| |
Abstract: | Amyloid deposits in cerebral vessels are common in β-amyloid diseases (Alzheimer’s disease, congophilic amyloid angiopathy,
Down’s syndrome and hereditary cerebral amyloidosis with haemorrhage of the Dutch type). We report of 20 autopsies on patients
who had died with systemic amyloidosis of the AA, Aλ and Aκ types: the brains were examined for the occurrence of amyloid.
Vascular amyloid was detected in choroid plexus (in 17 of 20 cases), infundibulum (5 of 8), area postrema (6 of 11), pineal
body (3 of 7) and subfornical organ (2 of 3), but not in cortical and leptomeningeal vessels. Immunohistochemical classification
of the cerebral amyloid and the systemic amyloid syndrome showed identity proving the same origin of both. The distribution
is indicative of a haematogenic pattern of amyloid deposition in systemic amyloidosis and is different from that in Alzheimer’s,
prion, ATTR and cystatin C diseases. It corresponds to areas of the brain with a ”leaky” blood–brain barrier. Additionally,
all the cases with AA amyloidosis exhibited an Aβ coreactivity in choroid plexus vessels. In one exceptional case, Aβ reactivity
of AA amyloid also occurred outside of the brain.
Received: 2 November 1998 / Accepted: 25 January 1999 |
| |
Keywords: | Systemic amyloidosis Brain Circumventricular organs Choroid plexus Immunohistochemistry Aβ colocalization |
本文献已被 SpringerLink 等数据库收录! |
|