Dopamine and serotonin metabolites in rat cerebroventricular fluid following withdrawal of haloperidol or electroshock treatment |
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| Authors: | A I Barkai S Kowalik A Reches |
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| Institution: | (1) New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, 10032 New York, NY, USA;(2) Department of Psychiatry, Columbia University College of Physicians and Surgeons, 10032 New York, NY, USA;(3) Department of Neurology, Columbia University College of Physicians and Surgeons, 10032 New York, NY, USA |
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| Abstract: | Levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and of the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were determined in the CSF of rats at various times after repeated electroshock treatment (EST) or chronic administration of haloperidol. The acidic metabolites were analyzed in 25  l CSF using HPLC with an electrochemical detector. A significant decrease in the CSF levels of DOPAC and HVA was found 4 days after the last administration of chronic haloperidol, EST, or both. The decrease in the level of the dopamine metabolites indicated a slower dopamine turnover, which might have resulted from hypersensitivity of presynaptic dopamine receptors after these treatments. Rats treated with haloperidol also showed an increase in 5-HIAA levels, possibly due to enhanced serotonin turnover. The 5-HIAA increase following haloperidol was prevented by a concurrent administration of EST, suggesting attenuation by EST of the haloperidol-induced enhancement of serotonin turnover. |
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| Keywords: | Electroshock treatment Haloperidol Dopamine metabolites 5-HIAA CSF Dopamine receptors |
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