氨基导眠能与己酸孕酮治疗子宫内膜癌的作用比较

将子宫内膜癌３９例以双盲法随机分为３组，分别用己酸孕酮、氨基导眠能或两药联合治疗。结果：（１）氨基导眠能使雌二醇（Ｅ２）、孕酮（Ｐ）含量下降，己酸孕酮使血中Ｐ含量增加，联合治疗后Ｐ增加、Ｅ２下降（Ｐ〈０．０５￣０．０１）。（２）己酸孕酮使雌激素受体（ＥＲ）、孕激素受体（ＰＲ）阳性率略下降（Ｐ〉０．０５），氨基导眠能及联合用药后ＥＲ阳性率显著下降（Ｐ〈０．０５）。（３）三种不同方法治疗后均出现癌细胞

Comparison between the Roles of Aminoglutethimide and Hydroxyprogesterone Caproates in the Treatment of Endometrial Cancer

bjective To compare the changes of serum levels and tissue receptor levels of estrogen and pro- gesterone as well as histopathological changes following treatments of endometrial cancer with amino- glutethimide(AG),progesterone caproate,or a combination of both. Method Thirty-nine patients of endometrial cancer were trea ted with hydroxyprogesterone caproate,AG or combination of both, and their effects were compared. Result It was observed that:(1)the administration of AG gave a fall of estradiol and proges- terone serum levels;hydroxyprogesterone caproates therapy increased the level of progesterone; and fol- fowing the combination treatment, higher progesterone and lower estradiol levels were found(P<0.05),(2)treatments by AG as well as by combination therapy brought about a considerable fall of the positive rate of ER and PR in tissues (P<0.05),(3)histological changes showed inhibition of cell growths in all three types of treatment,secretory cells and decidual reaction were shown under the influ- ence of hydroxyprogesterone caproates,the changes in combination therapy mainly complied with those in AG treatment. Couclusion The results suggested that AG was effective in treating patients with endometrial can- cer,resulting in changes of endocrine environments and inhibition of cell growth by mechanism different from that of hydroxyprogesterone caproates.