肿瘤抑制基因p53在卵巢移行细胞癌中的过度表达

采用单克隆本免疫组化技术，对３２例卵巢称行细胞癌组织进行肿瘤抑制基因Ｐ５３表达的检测，分析Ｐ５３过度表达与卵巢移行细胞癌预后诸因素间的相关性。结果：卵巢移行细胞癌Ｐ５３表达率为４１％。

Overexpression of p53 in transitional cell carcinoma of the ovary

o determine the prevalence of p53 abnormal protein expression in transitional cell carcinoma of the ovary in Peking Union Medical College hospital,and to analyse the correlation between the overexpres-sion of p53 protein and prognostic parameters of transitional cell carcinoma of the ovarv,thirtv-two transitional cell carcinoma of the ovary and 20 normal ovaries were analysed.Detection of overexpression of p53 protein was carried out by immunohistochemical staining ( IHS ) using the monoclonal antibodyDO-1 on paraffin sections. 41/of 32 saniples of transitional cell carcinon1a of the ovary showed positiveIHS with DO-1,wherease only 5%of 20 normal ovaries showed weakly positive cytoplasmic staining(P<0. 01).p53 overexpression did not correlate with age,CA_125 levels,histological grade and lymph node metastasis,but patients with overexpression of p53 had a poor prognosis. Overexpression of p53 is amore common event in transitional cell carcinoma of the ovarv. Further studies are warranted to clarify the role of p53 in transitional cell carcinoma of the ovary.