| 二氢杨梅素制剂新技术与新剂型的研究进展 |
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| 引用本文： | 向东,熊微,王文清,施春阳,侯小龙,方建国.二氢杨梅素制剂新技术与新剂型的研究进展[J].中草药,2016,47(4):689-694. |
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| 作者姓名： | 向东 熊微 王文清 施春阳 侯小龙 方建国 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院药学部, 湖北武汉 430030;华中科技大学同济医学院附属同济医院药学部, 湖北武汉 430030;华中科技大学同济医学院附属同济医院药学部, 湖北武汉 430030;华中科技大学同济医学院附属同济医院药学部, 湖北武汉 430030;华中科技大学同济医学院附属同济医院药学部, 湖北武汉 430030;华中科技大学同济医学院附属同济医院药学部, 湖北武汉 430030 |
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| 基金项目： | 国家自然青年科学基金资助项目(81503013);华中科技大学创新研究院技术创新基金(CXY13Q059) |
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| 摘 要： | 二氢杨梅素是植物显齿蛇葡萄中主要的黄酮类化合物,近年来其药理作用和制剂工艺受到业界广泛的关注。二氢杨梅素药理作用确切,但其自身理化性质和生物利用度低限制了该药物的临床应用,研究制剂新技术与新剂型改善其理化性质已逐渐成为研究的热点。通过查阅国内外相关文献,综述了近年来二氢杨梅素制剂新技术与新剂型如脂质体、微囊、微乳、固体分散体、包合物、胃漂浮制剂等的研究进展,指出目前研究的不足,为今后研究提供参考。
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| 关 键 词： | 二氢杨梅素 制剂新技术 新剂型 溶解性 生物利用度 |
| 收稿时间： | 6/9/2015 12:00:00 AM |
Research progress on advanced pharmaceutical preparation and new dosage forms of dihydromyricelin |
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| XIANG Dong,XIONG Wei,WANG Wen-qing,SHI Chun-yang,HOU Xiao-long and FANG Jian-guo.Research progress on advanced pharmaceutical preparation and new dosage forms of dihydromyricelin[J].Chinese Traditional and Herbal Drugs,2016,47(4):689-694. |
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| Authors: | XIANG Dong XIONG Wei WANG Wen-qing SHI Chun-yang HOU Xiao-long and FANG Jian-guo |
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| Institution: | Department of Pharmacy, Tongji Hospital Affiliated with the Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Pharmacy, Tongji Hospital Affiliated with the Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Pharmacy, Tongji Hospital Affiliated with the Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Pharmacy, Tongji Hospital Affiliated with the Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Pharmacy, Tongji Hospital Affiliated with the Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Pharmacy, Tongji Hospital Affiliated with the Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | As a major flavonoid in the leaves of Ampelopsis grossedentata, dihydromyricelin has attracted wide attention in recent years. The pharmacological effect of the dihydromyricelin is clear, but the limitation on the clinical application of this drug comes from its chemical properties and low bioavailability. Nowadays, researching on advanced pharmaceutical preparation and new dosage forms in order to improve its chemical properties has become hot spots. Based on the review of related literatures, we discussed the research progress on advanced pharmaceutical preparation and new dosage forms of dihydromyricelin, such as liposomes, microcapsules, microemulsions, solid dispersion, inclusion compound, floating gastroretentive drug, etc. The main purpose is to point out the shortages of existing research and provide a reference for further study. |
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| Keywords: | dihydromyricelin advanced preparation technology new dosage forms solubility bioavailability |
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