猫中缝大核向间脑、脑干和脊髓的投射——放射自显影和溃变法研究

<正> 近代神经解剖学将脑干中缝的核团命名为中缝核或缝际核(Nuclei raphe)。Tabet等又把猫中缝核分为8个核团。DahIstrom等用荧光组织化学的方法,进一步研究了大白鼠脑干5-羟色胺神经元胞体的分布,并将其分为9群。而且证明中缝核团

THE PROJECTIONS OF THE NUCLEUS RAPHE MAGNUS ONTO THE INTERBRAIN,BRAINSTEM AND SPINAL CORD IN THE CAT: AN AUTORADIOGRAPHIC AND DEGENERATIO NSTUDY

A totai of 35 cats were used in this investigation. Following sterectaxic injections ~3H-Leucine or electrolytic lesions in the nucleus raphe magnus, efferent fibers were observed to emerge from the nucleus raphe magnus. The terminations were examined microscopically under brightfield and dark-field illumination. The terminal fields were distributed as follows Ascending fibers of nucleus raphe magnus were found in the nucleus parafascicularis and nucleus centralis of the thalamus, posterior area of the hypothalamus, central gray matter and reticular formation of midbrain. A few fibers were terminated in the nucleus raphe pontis, nucleus reticularis pontis, nucleus posterior commissure, superior colliculus, nucleus interpeduncularis and the pretetal area. Descending fibers of the nucleus raphe magnus terminated in the nucleus reticularis gigantocellularis, nucleus reticularis paramedianus, nucleus olivaris inferior, nucleus tractus solitarii,nucleus motorius dorsalis ncrvi vagi and the marginal, gelatinous and magnocellular layer of the. spinal trigeminal nucleus caudalis. The projection to the spinal cord is bilateral, via the dorsolateral funiculus. Terminal fields are found in the lamina Ⅰ Ⅱ and Lamina Ⅴ-Ⅶ of the dorsal horn and intermediate zone. In summary, the efferents of nucleus raphe magnus not only directly connect with the structure of the pain control but also with many of the other nuclei. It suggests that the nucleu raphe magnus is an important relay station for pain control.