早发性卵巢功能不全激素补充治疗

早发性卵巢功能不全（POI）是指女性40岁之前卵巢活动衰退，对患者健康造成严重不良影响的临床综合征。POI患者更需要激素补充治疗（HRT），并且HRT风险更低，只要没有禁忌证，应积极推荐POI患者使用HRT以缓解症状并降低远期风险。POI患者建议应用系统性HRT，推荐序贯方案。所需雌激素剂量相对更高，孕激素剂量需根据雌激素的剂量相应调整。HRT用药期间应定期检查并评估利弊，建议长期应用，至少持续至正常绝经年龄。

Hormone replacement treatment in women with premature ovarian insufficiency

Premature ovarian insufficiency（POI） describes a spectrum of declining ovarian function in women younger than 40 years，which has severe influence on health.In women with POI，hormone replacement treatment（HRT）is required and with lower risks.HRT is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment.Systemic HRT with cyclic administration is recommended.The dose of estrogen in women with POI is higher，and the dose of progesterone is adjusted according to the dose of estrogen.During treatment evaluation for all women with POI should be done，and the treatment should last at least until the average age of natural menopause.