慢性肾功能衰竭患者血清瘦素与中医证型关系的研究

目的:探讨慢性肾功能衰竭(CRF)患者血清瘦素浓度对营养状况的影响以及与CRF中医证型的关系.方法:CRF组110例按中医辨证分成5个证型亚组,并设正常对照组30例.采用酶联免疫法测定血清瘦素浓度,并测量身高、体重,计算体质指数(BMI);CRF组同时测定血清白蛋白、血清前白蛋白、转铁蛋白、血清肌酐、尿素氮、C反应蛋白、血胰岛素,并计算营养风险指数(NRI).结果:CRF组血清瘦素水平高于正常对照组,CRF组中脾肾气(阳)虚证两亚组血清瘦素水平、营养客观指标水平与其他3个亚组比较,差异均有显著性.结论:高瘦素血症可能是导致CRF患者营养不良的原因之一,脾肾气(阳)虚证血清瘦素水平明显高于非脾肾气(阳)虚证,推测血清瘦素可能是CRF脾肾气(阳)虚证的部分物质基础.

Study on Relation between Serum Leptin and TCM Syndrome Types in the Patient of Chronic Renal Failure

Objective:To explore effect of serum leptin level on nutriture in the patient of chronic renal failure(CRF)and the relation with TCM syndrome types of CRF.Methods:110 cases in CRF group were divided into 5 subtypes and 30 normal persons were used as control group.Serum leptin level,body height,body weight,and body mass index(BMI)were determined in both groups;and serum albumin,serum pre-albumin,transferin,serum creatinine,urea nitrogen,C-reaction protein,blood insulin,and nutrition risk index(NRI)were detected in CRF group.Results:Serum leptin level in CRF group was higher than that in the control group,and leptin level and nutritional index level in both the subtype groups of Qi-and Yang-deficiency of spleen and kidney were significantly different with those in other 3 subtype groups.Conclusion:High blood leptin is possibly one of the reasons inducing malnutriture of CRF patient,and serum leptin is possibly a partial basis of substances of Qi-and Yang-deficiency syndrome of CRF.