| 心肺转流术中红细胞抗氧化活性与机体氧化应激水平的关系 |
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| 引用本文： | 顾家珍,夏芳,张遵严,罗涛,夏正远.心肺转流术中红细胞抗氧化活性与机体氧化应激水平的关系[J].微循环学杂志,2005,15(2):23-25. |
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| 作者姓名： | 顾家珍 夏芳 张遵严 罗涛 夏正远 |
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| 作者单位： | 1. 武汉大学人民医院麻醉科,武汉,430060
2. 武汉大学人民医院胸外科 |
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| 基金项目： | 国家自然科学基金课题 (3 0 47165 9) |
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| 摘 要： | 目的:研究红细胞(RBC)抗氧化活性作为心肺转流术(CPB)患者氧化应激反应水平指标的可行性。方法:8例行主动脉-冠状动脉搭桥术的患者,分别于不同时相测定其中心静脉血中RBC抗氧化物丙二醛(MDA)和血浆游离异前列腺素15-F2t-Isoprostane(15-F2t-Imp)浓度。结果:在CPB和缺血再灌注损伤(IRI)过程中MDA产生明显增加,血浆游离15-F2t-Isop浓度显著增高,两者间存在明显正相关。结论:在CPB过程中,RBC抗氧化活性反映了机体氧化应激状态,是评价患者CPB时体内氧化应激水平的良好指标。
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| 关 键 词： | 红细胞 抗氧化活性 心肺转流术 丙二醛 异前列腺素15-F2t-Isop |
| 文章编号： | 1005-1740(2005)02-0023-03 |
| 修稿时间： | 2004年10月26 |
Correlation Between the Activity of Erythrocyte Antioxidantion and the Level of Oxidant Stress During Cardiopulmonary Bypass |
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| Gu Jiazhen,Xia Fan,Zhang Zunyan,et al/.Correlation Between the Activity of Erythrocyte Antioxidantion and the Level of Oxidant Stress During Cardiopulmonary Bypass[J].Chinese Journal of Microcirculation,2005,15(2):23-25. |
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| Authors: | Gu Jiazhen Xia Fan Zhang Zunyan / |
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| Institution: | Gu Jiazhen,Xia Fan,Zhang Zunyan,et al/Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060 |
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| Abstract: | Objective: To investigate whether red blood cell (RBC) antioxidant activity predicts alterations in oxidant stress during cardiopulmonary bypass (CPB) in humans. Method: 8 patients, scheduled for ACBP. Central venous blood was taken for evaluation of RBC antioxidant capacity (MDA) and to determine the concentration of plasma free 15-F2t-Isoprostane. Results: In IRI of process of CPB,the produce of MDA increased,also the concentration of 15-F2t-Isoprostane increased too. So that, There are clear correlation between the MDA and 15-F2t-Isoprostane. Conclusion: The antioxidant activity is to show the oxida-tive condition in organism with process of CPB. It may be to evaluate the level of oxidative stress in patients during IRI of process of CPB. |
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| Keywords: | Erythrocyte Antioxidant activity Cardiopulmonary bypass MDA 15-F2t-Isoprostane |
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