SBP1和Caspase-3在人乳腺癌组织中的表达及意义

目的观察人乳腺癌组织中硒结合蛋白1（SBPl）和凋亡调节蛋白（Caspase-3）的表达，探讨SBPl和Cas-pase-3在乳腺癌发生、发展过程中的作用及其相互关系。方法用免疫组织化学ABC法检测乳腺癌中SBPl和Caspase-3的表达水平，并与癌旁相对正常组织、乳腺良性病变组织进行比较分析。结果SBP1、Caspase．3在癌旁相对正常乳腺组织中的阳性表达率为100％、86．6％；在乳腺良性病变组织的阳性表达率为93.3％、73．3％；在乳腺癌组织的阳性表达率为82．1％、57．1％。乳腺癌组织中SBP1和Caspase．3的表达水平均明显低于癌旁相对正常组织和乳腺良性病变组织。乳腺癌组织中SBPl与Caspase-3的表达呈正相关。结论乳腺癌组织中SBP1和Caspase-3的表达下调，提示SBPl可能通过促进肿瘤细胞的凋亡来抑制肿瘤的增殖，为进一步对硒诱导SBPl治疗乳腺癌的作用研究提供基础。

Expression and significance of SBP1 and Caspase-3 in human breast cancer

Objective To investigate the relationship of the expression of SBP1 and Caspase-3 in human breast cancer. Methods The human breast cancer tissues, para-carcinoma breast tissues and breast benign lesions were collected, the expres- sion of SBP1 and Caspase-3 in tissues were detected by immunohistochemistry, and the correlation between SBP1 and Caspase-3 were assessed by statistical approach. Results The expression rate of SBP1 and Caspase-3 were 100% and 86.6% in para- carcinoma breast tissues, 93.3% and 73.3% in breast benign lesions, 82.1% and 57.1% in breast cancer tissues, respectively. Expression rate of SBP1 and Caspase-3 in breast cancer tissues was significantly lower than that in para- carcinoma breast tis- sues and breast benign lesions （P〈0.05）. SBP1 and Caspase-3 expressions were positively correlated（P〈0.05）. Conclusion Down-regulation of SBP1 and Caspase-3 in breast cancer tissues suggest that SBP1 may inhibit tumor growth by promoting apop- tosis of tumor ceils, which may provide a basis for future studies to use selenium to treat breast cancer.