慢性肾病患者红细胞免疫功能与脂质过氧化的关系

目的 研究慢性肾病患者红细胞免疫功能的变化及其与脂质过氧化的关系.方法 应用红细胞酵母花环法测定33例慢性肾病患者红细胞免疫功能和化学比色法测定血浆丙二醛(MDA)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量,并与35例健康人比较.结果 慢性肾病患者红细胞免疫复合物(RBC-ICR)花环百分率和MDA水平明显升高(P＜0.01),而红细胞C3b受体(RBC-C3bRR)、SOD、GSH-PX明显低于正常(P＜0.01).相关分析显示,RBC-C3bRR 花环与MDA呈显著负相关(r=-0.4812,P＜0.05).RBC-ICR与MDA 呈正相关(r=0.5128,P＜0.05).结论 慢性肾病患者红细胞免疫功能的降低,与活性氧代谢紊乱密切相关.

Study on relationship between red blood cell immune function and lipid peroxidation in patients with chronic nephrophy

Objective To study the relationship between red blood cell immune function and lipid peroxidation (Lpo)in patients with chronic nephrophy.Methods Red cell yeast-rosttes test was applied to detect RBC immune function in 33 patients with chronic nephrophy and 35 healthy controls.Plasma levels of malondialdehyde(MDA), superoxidase(SOD)and glutathione peroxidase(GSH-PX)were measured by cbemocolorimetry in these subjects.Re- sults The percentage of positive RBC-ICR and MDA level were significantly higher in patients with chronic nephro- pby than those in controls(P<0.01),while RBC-C_3 bRR,SOD,GSH-PX levels were significantly lower in patients with chronic nephrophy than those in controls(P<0.01).The percentage of positive RBC-C_3 bRR was negatively correlated with MDA level(r=-0.4812,P<0.05)and RBO-ICR was positively correlated with MDA(r=0.512 8,P<0.05).Conclusion The decreased red cell immune function is closely associated with disorder of metabolism of lipid peroxidation in patients with chronic nephrophy.