老年高血压患者降压治疗后动态动脉僵硬度指数研究

目的 观测老年高血压患者降压治疗后动态动脉僵硬度指数（ambulatory arterial stiftness index，AASI）的结果及其对评估动脉硬化和预测心血管事件的作用。方法 观测99例住院老年高血压患者，男性87例；女性12例，平均年龄78．03±6．36岁。记录其在连续接受降血压治疗6个月后的相关资料（高密度脂蛋白检测，24小时动态血压测定，动态动脉僵硬度指数及脉压、脉压指数）并进行回顾性分析。结果动态动脉僵硬度指数与脉压指数呈中度正相关（r=0．381，P〈0．001），与高密度脂蛋白呈负相关（r=-0．252，P=0．013）。结论提示对于接受降压治疗的老年原发性高血压患者，动态动脉僵硬度指数可作为动脉硬化评估的参考指标，有望成为心血管危险的预测因子。

Investigation of ambulatory arterial stiffness index in elderly hypertensive patients after antihypertensive therapy

Objective To detect ambulatory arterial stiffness index （AASI） and observe its role in assessing arteriosclerosis and predicting cardiovascular events in hypertensive patients who were on antihypertensive therapy. Methods Data of 99 elderly patients （87 men and 12 women; mean age 78.03 ＋6.36 years） with primary hypertension were analyzed respectively. All patients were continuously treated with hypotensors for more than six months, during which high density lipoprotein, ambulatory blood pressure, ambulatory arterial stiffness, pulse pressure and pulse pressure index were recorded.Results There was a positive correlation between AASI and pulse pressure index （r = 0.381, P〈0.001）, and a negative correlation between ambulatory arterial stiffness index and high density lipoprotein （r = - 0.252, P = 0.013）. Conclusions The results of the present study suggest that AASI could be used as a reference for assessing arteriosclerosis, and would hopefully be a factor for predicting cardiovascular risks in elderly hypertensive patients who are on antihypenensive therapy.