脑脊液内细胞移植治疗脊髓损伤

经脑脊液进行细胞移植治疗脊髓损伤具有较大的临床应用前景.有关研究显示,经脑脊液进行的细胞移植方法安全、方便,对病人的损伤小,适用于治疗中枢神经系统多发疾病.但是经脑脊液移植的细胞能否促进中枢神经系统轴突再生和脊髓神经功能修复仍存在争议,其作用机制、移植时间以及移植细胞种类方面还需要进一步研究.本文对经脑脊液细胞移植方法用于治疗脊髓损伤进行综述,探讨此方法对脊髓损伤后中枢神经系统内轴突再生及功能修复的促进作用.

Treatment of spinal cord injury by transplantation of cells via cerebrospinal fluid

It is very important to probe into the axonal regeneration and functional recovery of central nervous system (CNS) after implantation of cells into cerebrospinal fluid (CSF) for spinal cord injury (SCI). Transplantation of cells via CSF poses great potentials for SCI in clinic. Studies on administration of cells via CSF indicate that the method is safe and convenient. The method is more suitable to treating multiple lesions of the CNS since it does not produce open lesions. However, there are disputes over its promotion effects on axonal regeneration and functional recovery of spinal cord after injury; and some questions, such as the mechanisms of functional recovery of spinal cord, the proper time window of cell transplantation, and cell types of transplantation, still need to be handled. This review summarized the method of cell transplantation via CSF for treatment of SCI.