Norplant皮下埋植避孕法使用七年临床观察

目的 评价单纯孕激素避孕埋植剂Ｎｏｒｐｌａｎｔ在我国妇女和的效果及副反应。方法 １９８４年始在１２个中心及其分中心接受使用Ｎｏｒｐｌａｎｔ避孕的妇女共有１０７１８名,采用前瞻性方法进行５年观察;其中部分妇女继续使用至７年,对使用７年的临床效果观察。结果 在第５年时的年妊娠率为０．６３／１００妇女。共有７５５４名妇女使用满５年,３６２２名妇女使用满６年,２４３３名妇女使用满７年。第６、７年的年妊娠率

Clinical experience with 7 years of norplant

OBJECTIVE: To assess the efficacy, safety of Norplant implants used by Chinese women. METHOD: In a prospective, multicenter clinical trial, 10,718 women receiving Norplant implants were monitored annually through 5 years and part of women continuously used the implants up to 7 years. RESULTS: The five-year pregnancy rate was 0.63/100 users. 7,554 women completed 5 years, 3,622 women completed 6 years and 2,433 women completed 7 years. The annual pregnancy rates were 0.40/100 users in both year 6 and year 7. The pregnancy rates increased with weight (P < 0.05) and decreased with age. The menstrual disturbances were common, also the main reason for discontinuation. Headache, dizziness and weight gain led to termination more frequently than did other adverse events apart from menstrual disturbances. The 5-year continuation rate was 72.1/100 users. Among aged > 30 and weight < 60 kg, the implants may be used for 7 years. CONCLUSION: It's proved that the Norplant implants is a highly effective, long acting, safe, simple and reversible contraceptive method, and it is acceptable in Chinese women.