解脲支原体感染与早产及胎膜早破的关系

目的 探讨解脲支原体（ＵＵ）感染与早产及胎膜早破的相关性。方法 采用分离培养法,分别对４６例胎膜早破和７例早产患者（试验组）以及３２例正常妊娠（对照组）妇女的宫颈分泌物,胎膜和脐带进行了ＵＵ检测;对部分试验组和对照组的胎盘组织进行电镜观察,并与阳性培养物负染电镜观察结果引比较,结果 试验组宫颈分泌物,胎膜和脐带中ＵＵ检出率为均为７３．６％（３９／５３）,对照组宫颈,胎膜和脐带中的ＵＵ检出率分别为４

Ureaplasma urealyticum infection and premature delivery or premature rupture of the membrane

Objective To evaluate the relationships between ureaplasma urealyticum (UU) infection and premature delivery or premature rupture of the membrane (PROM). Methods The cervical swabs, fetal membrane and umbilical cord from 46 cases of PROM, 7 cases of premature delivery (study group), and 32 normal pregnancies (control group) were cultutred for UU. Some of these placenta tissues were examined under electron microscopy, and compared with the purified UU. Results The detective rates of UU were both 73.6%(39/53) in the cervix and fetal membrane of the study group, and to compare with the control group (40.6%, 13/32 and 15.6%, 5/32 respectivety), significant differences were shown (P<0.01, P<0.001). The prevalence rate of perinatal mortality, stillbirth and low birth weight in UUpositive cases (34.1%, 15/44) was significantly higher than that in UUnegative cases (7.3%, 3/41, P<0.01). Electron microscopy demonstrated that large amount of small multiplicated UU particles deposited around the nuclear membrane of the cytotrophoblasts and in the collagen fibers from the placenta of PROM, and its shape was in consistent with that of the purified UU. In contrast, no UU particles was seen in the normal control group. Conclusion the results show that UU is responsible for some cases of premature delivery, low birth weight and PROM. The multiplication of UU within the trophoblasts may disrupt cell structure which could interfere the normal fetal development.