放射免疫显像在恶性滋养细胞疾病诊断中的应用

目的 探讨放射免疫显像用于恶性滋养细胞疾病诊断的效果。方法 应用＾１３１Ｉ标记的小鼠抗人绒毛膜促性腺激素单克隆抗体,对２１例恶性滋养细胞疾病患者进行２４例次放射免疫显像、观察其对病灶的定位效果。结果 ２４例次放射免疫显像中,阳性１３例次（其中假阳性１例次）,阴性１１例次（其中假阴性２例次）。病灶定位的敏感性为８５．７％,特异性为９０．０％,准确性为８７．５％,在８例手术患者中,放射免疫显像所见与病

Radioimmunodetection in the diagnosis of trophoblastic disease

Objective To study the efficiency of edioimmundetection (RID) to locate the loci of trophoblastic disease. Method 24 RlDs were performed with 131I labeled mouse anti-hCG monoclonal antibodes on 21 patients with trophoblastic disease. Results of 24 RIDs performed, 13 were positive, including one false positive; 11 were negative, including two false negative. The sensitivity of RID was 85. 7%, the specificity was 90.0%, the accuracy was 87.5%. In 8 patients who undrwent opehtions after RID, the findings of RID were in accordance with the pathologic and immunohistologic findings. Conclusions RID is an efficient imaging method for trophoblastic disease. In some cases, RID showed its value as a functional diagnostic methood.