Efficient construction of the securine A carbon skeleton |
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Authors: | Korakas Peter Chaffee Stuart Shotwell J Brad Duque Pamela Wood John L |
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Affiliation: | Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, CT 06514, USA. |
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Abstract: | Securamine A is a structurally intriguing alkaloid possessing a pyrroloindole core joined via a modified isoprene subunit to a functionalized imidazole ring. Recent synthetic efforts in this laboratory have resulted in the efficient construction of key lactone 36, which undergoes tandem azide reduction/ring expansion to macrolactam 37. Macrolactam 37 possesses the complete macrocyclic core of securamine A. |
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