大鼠腹腔注射荷包牡丹碱和阿托品对电针镇痛效应及其脑内去甲肾上腺素含量变化的影响

<正> 我们以前的研究发现,针刺镇痛时大鼠脑内去甲肾上腺素(NA)含量发生明显变化,而且它与针刺镇痛有密切的关系。许多研究资料也支持中枢 r-氨基丁酸(GABA)和乙酰胆碱(ACh)参与针刺镇痛过程。由于脑内各种神经介质在代谢和功能上存在密切的联系和动态平衡。在本工作中,我们观察了大鼠腹腔注射

EFFECTS OF INTRAPERITONEAL INJECTION OF BICUCULLINE OR ATROPINE ON ELECTROACUPUNCTURE ANALGESIC EFFECT AND THE CHANGE OF BRAIN NORADRENALINE CONTENT IN RATS

Sixty of rats were randomly divided into 6 groups:(1)Control;(2)Electroacupuncture(EA);(3)Bicuculline;(4)Bicuculline plus EA;(5)Atropine;(6)Atropine plus EA.The contents of noradrenaline (NA)in brain stem,diencephalon and telencephalon were determined by fluorcspectro-photometry.It was found that the pain threshold increased and the NA level in the telencephalon decreased markedly after EA.Bicuculline injection decreased the analgesic effect of EA by 77.7%,abolished the EA-induced decrease of NA content in the telencephalon and decreased the NA level in the brain stem after EA.Atropine decreased the analgesic effect of EA by 76.6% and decreased the NA contents in the brain stem and the dienc(?)phalon after EA.These results suggest that both GABA arid muscarinic c(?)olinergie receptors may play important roles in EA analgesia and this may be partially carried out through the brain NA system.