喹诺酮类药治疗复治耐多药肺结核的成本-效果分析

目的：在环丙沙星、氧氟沙星、左氧氟沙星、司帕沙星中寻找治疗复治耐多药肺结核病的最佳方案。方法：利用已有的文献资料，采用成本-效果分析方法进行评价；同时对可能的影响因素（价格）进行考察，并作敏感性分析。结果：在痰菌转阴率比较中，左氧氟沙星与司帕沙星效果相近，优于环丙沙星和氧氟沙星（P〈0．05）；空洞关闭率、X线病灶有效率、不良反应发生率等指标各组间比较无统计学意义（P〉0．05）。各组间的医疗费用差异有统计学意义。结论：左氧氟沙星为最佳治疗方案。敏感性分析与成本-效果分析的结果一致。

Cost-effectiveness Analysis of Four Kinds of Oral Fluoroquinolones for Retreating Multi-drug Resistant Pulmonary Tuberculosis

Objective:To select a best therapeutic scheme for retreating multi-drug resistant pulmonary tuber-culssosis among the four kinds of fluoroquinolones:Ciprofloxacin(C) , Ofloxacin(O) , Levofloxacin( V) , and Sparfloxacin ( Sp). Method: According to the principle of pharmacoeconomics, using cost-effectiveness analysis (CEA) , the assessment and survey of the influencing factors (price) were carried out, and at the same time, a sensitive analysis was performed. Result:In the comparison of the sputum negative conversion rate, the bacteria rate of group O was similar to that of group C(P>0.05). Group V resembled group Sp(P>0.05);Group V and group Sp dwarfed group C and group O respectively (P > 0.05). There was no statistical significance in the effect rates of X-ray examined focus or closure rates of cavities in the research groups (P>0.05); There was no statistical significance in the rate of adverse reactions (P >0.05). There were significant differences in cost among the four groups. Conclusion:Levofloxacin is the most effective and inexpensive scheme. The result of the sensitive analysis is in keeping with that of CEA, which indicates the credibility of CEA.