二硫化碳接触工人体内一氧化氮水平的初探

目的　探讨二硫化碳 (CS2 )作业工人体内一氧化氮 (NO)水平的变化及其机制。　方法选取某化纤厂CS2 作业工人 6 0名和不接触CS2 工人 36名 ,分别测定血浆NO、脂质过氧化物 (LPO)水平及红细胞超氧化物歧化酶 (Ery SOD)活性。结果　高、低剂量接触组工人血浆NO水平分别为(4 3 2 8± 19 83)和 (5 0 0 7± 2 1 0 1) μmol/L ,与对照组 (70 6 6± 2 6 83) μmol/L比较 ,两者均显著降低 ;高、低剂量接触组工人Ery SOD活性分别为 4832 2 1和 3 5 2 0 80u/gHb ,与对照组 (2 42 5 34u/gHb)比较 ,高剂量组显著升高 ;高、低剂量接触组工人血浆LPO水平分别为 19 38和 17 0 9μmol/L ,与对照组(4 37μmol/L)比较 ,均显著增高。结论　职业性长期接触CS2 能导致体内血浆NO水平下降 ,其机制与CS2 诱导体内超氧阴离子水平升高有关

A preliminary study on body level of nitric oxide in workers exposed to carbon disulfide

OBJECTIVE: To study changes in body plasma level of nitric oxide (NO) in workers exposed to carbon disulfide (CS(2)) and its possible mechanism. METHODS: Plasma levels of NO and lipid peroxide (LPO) and activity of erythrocyte superoxide dismutase (Ery-SOD) were determined in the workers exposed and unexposed to CS(2) in a chemical synthetic fiber works. RESULTS: Level of NO was (43.28 +/- 19.83) and (50.07 +/- 21.01) micromol/L in high- and low-dose exposed groups, respectively, significantly lower than that in the control group, which was (70.66 +/- 26.83) micromol/L (P < 0.05). Activity of Ery-SOD was 4 832.21 u/g Hb and 3,520.80 u/g Hb in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 2,425.34 u/g Hb (P < 0.05). Level of LPO was 19.38 and 17.09 micromol/L in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 4.37 micromol/L (P < 0.05). CONCLUSION: Occupational long-term exposure to CS(2) could induce reduction of NO level in the body with its mechanism related to increase of super-oxygen cation O(2)(*-) induced by CS(2).