| 脱矿人牙骨基质与聚乳酸膜复合体修复骨缺损的研究 |
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| 引用本文： | 肖骏,刘俊宾,夏仁云,陈安民,阎玉华.脱矿人牙骨基质与聚乳酸膜复合体修复骨缺损的研究[J].华中科技大学学报(医学版),2002,31(5):560-563. |
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| 作者姓名： | 肖骏 刘俊宾 夏仁云 陈安民 阎玉华 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院骨科,武汉,430030
2. 武汉理工大学生物材料和工程研究中心,武汉,430070 |
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| 摘 要： | 研究脱矿人牙骨基质与聚乳酸腹复合体修复骨缺损的特点及机制。采用Wistar大鼠共60只，随机分A、B、C3组，在其双侧桡骨中段制作4mm的骨缺损模型。右侧作为实验侧、缺损区A组植入脱矿人牙骨基质、B组仅外包裹聚乳酸膜、C组植入二者复合体。左侧为空白对照，分别于2、4、6、10周处死动物，标本行放射学及组织学检查。X线及组织切片均证实该复合体在6周时已有致密骨组织形成，10周时已有新生髓腔生成。表明脱矿人牙骨基质与聚乳酸膜复合体有良好的成骨能力，有引导骨组织再生、防止骨不连作用，无论是成骨速度与质量均优于单纯成分植入。
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| 关 键 词： | 骨移植 聚乳酸 骨形态发生蛋白 脱矿人工骨基质 |
| 修稿时间： | 2001年12月27 |
Bone Defect Repair with Complex of Demineralized Dentin Matrix and Polyactic Acid Membrane |
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| Xiao Jun,Liu Junbin,Xia Renyun et al.Bone Defect Repair with Complex of Demineralized Dentin Matrix and Polyactic Acid Membrane[J].Journal of Huazhong University of Science and Technology(Health Sciences),2002,31(5):560-563. |
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| Authors: | Xiao Jun Liu Junbin Xia Renyun |
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| Institution: | Xiao Jun,Liu Junbin,Xia Renyun et al Department of Orthopaedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | The characteristics and mechanism of the bone defect repair with the complex of demineralized dentin matrix (DDM) and polyactic acid (PLA) membrane were studied. Sixty Wistar rats with bilateral radius bone defects were divided into three groups: A, B and C. On the right side, the defect was covered with the DDM, PLA and the complex of DDM and PLA in the groups A, B and C, respectively. The defects on the left side served as controls correspondingly. The rats were killed at the 2nd, 4th, 6th, 10th week. Samples were treated for radiological and histological studies. In the experimental sides the bone defects were healed. New bone appeared in the way of intramembranous ossification and entochondrostosis. It was suggested that the complex of DDM and PLA membrane has the effects on guiding bone regeneration and preventing from nonunion. In the speed and quality of bone regeneration, the complex of DDM and PLA membrane excel DDM or PLA membrane only. |
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| Keywords: | bone grafting polyactic acid bone morphogenetic protein demineralized dentin matrix |
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