榼藤子种仁化学成分研究

 目的研究豆科植物植藤子[Entada phaseoloides(L.)Merr.]种仁的化学成分。方法采用硅胶,Sephadex LH-20等分离纯化,通过理化常数测定和现代波谱学技术(MS、¹H-NMR、¹³C-NMR)进行结构鉴定。结果分离得到8个化合物,分别为2,5-二羟基苯乙酸乙酯(1),2,5-二羟基苯乙酸甲酯(2),5-羟基-苯并呋喃-2-酮(3),榼藤酰胺A(4),硬脂酸甲酯(5),β-谷甾醇(6),胡萝卜苷(7),豆甾醇(8)。结论化合物1,3,5,7,8为首次从该属植物中分离得到,6为首次从该植物中分离得到。

Studies on Chemical Constituents in Seeds of Entada phaseoloide

OBJECTIVE To study the chemical constituents of Entada phaseoloides.METHODS The constituents were isolated and purified by the silica gel and Sephadex LH-20 chromatography,and their structures were elucidated based on their physieochemical properties and spectral data.RESULTS Eight compounds were isolated and identified as ethyl 2,5-dihydroxy phenyl acetate(1),methyl 2,5-dihydroxy phenyl acetate(2),5-hydroxybenzofuran-2(3H)-one(3),entadamide A(4),methyl stearate(5),β-sitosterol(6),β-daucosterol(7)and stigmasterol(8).CONCLUSION Compound 1,3,5,7 and 8 were isolated from Entada genus for the first time and compound 6 was isolated from Entada phaseoloides for the first time.