| 氨基酸结构类似物的合成 1.S-乙基-D,L-高半胱氨酸与 S-氨乙基半胱氨酸的合成 |
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| 引用本文： | 李绍英,陈昭,姚庆祥. 氨基酸结构类似物的合成 1.S-乙基-D,L-高半胱氨酸与 S-氨乙基半胱氨酸的合成[J]. 沈阳药科大学学报, 1986, 0(2) |
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| 作者姓名： | 李绍英 陈昭 姚庆祥 |
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| 作者单位： | 沈阳药学院制药系，沈阳药学院制药系，沈阳药学院化学制药教研室 44期毕业专题学生，44期毕业专题学生 |
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| 摘 要： | 本文介绍以蛋氨酸为原料合成 S-乙基-D,L-高半胱氨酸和以胱氨酸为原料合成S-氨乙基-L-半胱氨酸的简便方法。这二种氨基酸结构类似物可作为蛋氨酸、赖氨酸、苏氨酸以及异亮氨酸等菌种选育的代谢拮抗剂应用,以解除目的酸生物合成过程中关键酶的反馈抑制,从而达到提高这些氨基酸菌株的产酸率,增加氨基酸的产量。
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| 关 键 词： | 氨基酸结构类似物 胱氨酸 半胱氨酸 S-乙基-D L-高半胱氨酸 S-氨乙基-L-半胱氨酸 |
THE SYNTHESIS OF AMINO ACID ANALOGS Ⅰ.The Synthesis of S-Ethyl-D,L-Homocysteine and S-Aminoethyl-L-Cysteine |
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| Li Shaoying Chen Zhao Yao Qingxiang. THE SYNTHESIS OF AMINO ACID ANALOGS Ⅰ.The Synthesis of S-Ethyl-D,L-Homocysteine and S-Aminoethyl-L-Cysteine[J]. Journal of Shenyang Pharmaceutical University, 1986, 0(2) |
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| Authors: | Li Shaoying Chen Zhao Yao Qingxiang |
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| Affiliation: | Li Shaoying Chen Zhao Yao Qingxiang Department of Chemicalpharmaceutics |
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| Abstract: | S-Ethyl-D,L-homosysteine(D,L-ethionine)and S-aminoethyl-L-cysteine (AEC)are the amino acid analogs.This two analogs are used as the metabolic antagonists in the breeding of lysine,threonine isoleucine and methionine bacte- roum.The synthesis of D,L-ethionine have many methods on the literature.We design a simple synthetic method,“one-pot procedure”,the total yield of the D,L-ethionine is 59.04%(based on the methionine).The synthetic method of AEC,we also design a simple method,the total yield of AEC from cysteine is 40%. |
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| Keywords: | Amino acid analog Cystine Cysteine Methionine S-Ethyl-D L-homocysteine S-Aminoethyl-L-cysteine |
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