| 水蛭乙醇提取物体外抗凝血活性研究 |
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| 引用本文： | 冯光军,朱正光,余传林,张群,陈娜娜,雷林生,吴曙光.水蛭乙醇提取物体外抗凝血活性研究[J].中药材,2007,30(8):909-911. |
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| 作者姓名： | 冯光军 朱正光 余传林 张群 陈娜娜 雷林生 吴曙光 |
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| 作者单位： | 南方医科大学药学院药物研究所,广东广州,510515 |
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| 摘 要： | 目的:研究水蛭不同提取物对人血浆的抗凝活性及作用环节。方法:测定水蛭乙醇提取物不同萃取部位对凝血酶原时间(PT),凝血酶时间(TT),活化的部分凝血活酶时间(APTT),纤维蛋白原凝固时间(FCT)的影响。结果:水蛭的乙酸乙酯部位显著地延长人PT,APTT,TT和FCT;石油醚部位、正丁醇部位、水部位也有较弱抗凝活性。结论:水蛭乙酸乙酯提取部分抗凝作用最强,直接抑制凝血酶催化的纤维蛋白原凝固。
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| 关 键 词： | 水蛭 提取物 抗凝血 |
| 文章编号： | 1001-4454（2007）08-0909-03 |
| 修稿时间： | 2006-12-17 |
Study of Anticoagulant Activity of Ethanol Extracts from Leech in Vitro |
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| FENG Guang-jun,ZHU Zheng-guang,YU Chuan-lin,ZHANG Qun,CHEN Na-na,LEI Lin-sheng,WU Shu-guang.Study of Anticoagulant Activity of Ethanol Extracts from Leech in Vitro[J].Jorunal of Chinese Medicinal Materials,2007,30(8):909-911. |
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| Authors: | FENG Guang-jun ZHU Zheng-guang YU Chuan-lin ZHANG Qun CHEN Na-na LEI Lin-sheng WU Shu-guang |
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| Institution: | Institute of Pharmaceutical Science, College of Pharmaceutical Science, Southern Medical Unive~ity, Guangzhou 510515, China |
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| Abstract: | Objective:To study the anticoagulant activity of different portions of leech ethanol extracts(LEEs).Methods:Anticoagulant activity was determined by measuring prothrombin time(PT),thrombin time(TT),activated partial throboplstin time(APTT) and fibrinogen coagulation time(FCT).Results:PT,TT,APTT and FCT were remarkably prolonged by ethyl acetate portion of LEEs.Portions of petroleum ethrer,n-butanol and water extracted from LEEs was much weaker on anticoagulant activity.Conclusion:The anticoagulant effect of ethyl acetate extract portion of LEEs is the strongest among the four portions,and this results may be from its inhibitory effect on thrombin-catalyzed fibrinogen hydrolysis. |
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| Keywords: | Leech Extract Anticoagulant |
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