| 雷公藤抗生育成分的分离与生物测定 |
| |
| 引用本文： | 王淑云,张建伟,许烨,钱绍祯. 雷公藤抗生育成分的分离与生物测定[J]. 中国计划生育学杂志, 1994, 0(Z1) |
| |
| 作者姓名： | 王淑云 张建伟 许烨 钱绍祯 |
| |
| 作者单位： | 江苏省计划生育科学技术研究所 210029(王淑云，张建伟，许烨)，江苏省计划生育科学技术研究所 210029(钱绍祯) |
| |
| 摘 要： | 动物实验表明,卫矛科植物雷公藤粗提物的有效组分雷公藤多甙(GTW)可致雄性大鼠产生可逆性不育。因溶剂提取法分离雷公藤多甙片发现,所得到的水溶性部分含有抗生育活性成分。我们通过系统分组分离与生物测定结合的方法,采用反相高效液相色谱技术,对该水溶性部分进一步分离,以甲醇/乙腈/水为溶剂进行梯度洗朊,从中分得两个具有抗生育活性的单体,经光谱分析鉴定,分别为雷公藤乙素和雷醇内脂,两者均属二萜类化合物。
|
| 关 键 词： | 雷公藤 雄性抗生育 雷公藤乙素 雷醇内酯 |
Isolation and Bioassay of the Male Antifertility Compounds from Tripterygium Wilfordii. |
| |
| Wang Shu-yun,et al.. Isolation and Bioassay of the Male Antifertility Compounds from Tripterygium Wilfordii.[J]. Chinese Journal of Family Planning, 1994, 0(Z1) |
| |
| Authors: | Wang Shu-yun et al. |
| |
| Affiliation: | Wang Shu-yun,et al.Jiangsu Family Planning Institute,Nanjing,210029. |
| |
| Abstract: | The multiglycosides of Tripterygium wil-fordii (GTW),a crude extract of the Chineseherbal medicine Tripterygium wilfordii,causedreversible infertility in male rats. Bioassaywith sub-fractionation methods has been car-ried out on extracts of GTW. Two con-stituents of the plant with male antifertilityactivily have been isolated in pure form bypreparative HPLC using reverse phase col-umn. The structures of the two compoundswere identified on the basis of MMR and MSdata and were found to be tripdiolide and trip-tolidenol, respectively. |
| |
| Keywords: | Tripterygium wilfordii Male antifertility |
| 本文献已被 CNKI 等数据库收录！ |
|
