二甲双胍对合并代谢综合征的2型糖尿病患者代谢指数的影响

目的观察二甲双胍对合并代谢综合征的2型糖尿病患者代谢指数的影响。方法将45例正使用诺和灵30R治疗的合并代谢综合征的2型糖尿病患者随机分为两组，对照组维持原治疗方案，治疗组加用二甲双胍（0．5g3次／d）观察随访12周。结果治疗组与联合二甲双胍治疗前相比，联合二甲双胍治疗后空腹血糖，糖化血红蛋白（HbA1c），甘油三酯（TG），总胆固醇（TC），体质指数（BMI），腰围（WC）明显下降（尸〈0．001）。血压无明显改变。对照组的上述指标与治疗前相比差异无统计学意义（P〉0．05）。结论对合并代谢综合征的2型糖尿病患者联合应用二甲双胍可有效控制血糖、血脂，减轻体重。

Effects of metformin on metabolic indices in type 2 diabetic mellitus patients with metabolic syndrome

Objective To study the effects of metformin on metabolic indices in type 2 diabetic mellitus patients with metabolic syndrome.Methods 45 type 2 diabetes patients with metabolic syndrome who were using insulin Novolin 30R were grouped randomly by metformin (1.5 g daily) combined with insulin Novolin 30R (n =24) ,insulin Novolin 30R (n = 21) for 12 weeks.The metabolic indices of FPG,HbAlc,TG,TC,BMI,WC before and after treatment were observed.Results There were statistically significant difference in FPG,HbAlc,TG,TC,BMI,WC before and after treatment in metformin combined with insulin Novolin 30R group (P ＜ 0.001) compared with the use of only insulin Novolin 30R group (P ＞ 0.05).And there were no statistically significant difference in blood pressure in two groups.Conclusion Metformin has beneficial effects in effectively controlling blood glucose,blood lipids and weight loss in type 2 diabetic mellitus patients with metabolic syndrome.