| 急性脑梗死血浆凝血酶调节蛋白的动态监测 |
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| 引用本文： | 冯璞,张辉,杨丙义,郑永刚,谢晋辉,王英,李晋川,乔燕燕. 急性脑梗死血浆凝血酶调节蛋白的动态监测[J]. 中华脑血管病杂志(电子版), 2011, 5(4): 1-3 |
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| 作者姓名： | 冯璞 张辉 杨丙义 郑永刚 谢晋辉 王英 李晋川 乔燕燕 |
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| 作者单位： | 清华大学第二附属医院玉泉医院神经内科,北京,100049 |
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| 摘 要： | 目的探讨凝血酶调节蛋白（TM）作为一种血管内皮损伤标志物在临床检测中的意义。方法选择2003年2月至2006年2月我院门诊及住院的63例高血压患者和脑梗死患者为病例组。其中高血压病组37例,急性脑梗死组26例,另选择体检中心进行体检的43例健康者为对照组。采用ELISA方法检测高血压患者和急性脑梗死患者血浆TM浓度。统计学采用t检验,用SPSS10.0软件进行统计学处理（P〈0.05）。结果高血压患者血浆TM水平明显高于健康对照组。高血压合并脑梗死TM值增高;急性脑梗死在发病3～7d TM浓度最高;大面积脑梗死患者血浆TM水平比腔隙性脑梗死患者明显增高;头颅核磁梗死范围越大,血浆TM水平越高。结论血浆TM水平改变对脑梗死的分期、严重程度及其转归判断有临床意义。
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| 关 键 词： | 凝血酶调节蛋白 急性脑梗死 头颅核磁 |
Plasma thrombomdulin dynamic changes in acute cerebral infarction |
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| FENG Pu,ZHANG Hui,YANG Bing-Yi,ZHENG Yong-gang,XIE Jin-hui,WANG Ying,LI-chuan,QIAO Yan-yan. Plasma thrombomdulin dynamic changes in acute cerebral infarction[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Version), 2011, 5(4): 1-3 |
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| Authors: | FENG Pu ZHANG Hui YANG Bing-Yi ZHENG Yong-gang XIE Jin-hui WANG Ying LI-chuan QIAO Yan-yan |
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| Affiliation: | FENG Pu,ZHANG Hui,YANG Bing-yi,ZHENG Yong-gang,XIE Jin-hui,WANG Ying,LI Jin-chuan,QIAO Yan-yan.Department of Neurology,Yuquan Hospital,Tsinghua University,Beijing 100049,China |
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| Abstract: | Objective To study the clinical significance of thrombomdulin(TM) as a molecular marker indicating vascular endothelium injury.Methods Plasma conceneration of TM was measured in patients with hypertension and patients with acute brain infarction.Results Plasma level of TM significantly increased in hypertensive group.The TM levels of large area of brain infarction patients were higher than that of lacunar brain infarction.The bigger the area of the brain infartion in MRI image,the higher the level of TM con... |
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| Keywords: | Thrombomodulin Acute brain infaretion Brain MRI |
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