Do noninherited maternal antigens (NIMA) enhance renal graft survival? |
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| Authors: | J M A Smits Frans H J Claas Hans C van Houwelingen Guido G Persijn |
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| Institution: | (1) Eurotransplant Foundation, P. O. Box 2304, 2301 CH Leiden, The Netherlands Fax: +31 71 579 00 57, NL;(2) Eurotransplant Reference Laboratory, Department of Immunohematology and Blood Bank, University Hospital Leiden, Bldg 1, E3-Q, Postbus 9600, 2300 RC Leiden, The Netherlands, NL;(3) Department of Medical Statistics, University of Leiden, The Netherlands, NL |
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| Abstract: | To test the hypothesis that noninherited maternal antigens (NIMA) can modulate the alloreactivity of infant cells and provide
protection for renal transplant recipients, a study of renal transplantations performed between 1980 and 1991 was undertaken.
The survival rate of grafts with a mismatched antigen identical to the NIMA was compared to that of grafts in which the mismatched
antigen was not identical to the NIMA. In the case of HLA-A mismatches, graft survival rates were significantly better for
NIMA-mismatched transplants: 94 % and 83 % at 1 and 3 years, respectively, for single NIMA HLA-A mismatched transplants, and
83 % and 67 % when both HLA-A antigens were mismatched, compared to 76 % and 68 % (one non-NIMA HLA-A mismatch) and 67 % and
45 % (two non-NIMA HLA-A mismatches). Our results suggest that some class I NIMA-mismatched antigens are not harmful to renal
transplant recipients.
Received: 16 May 1997 Received after revision: 8 October 1997 Accepted: 19 November 1997 |
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| Keywords: | Noninherited maternal antigens kidney transplantation Acceptable mismatches kidney transplantation Immunological tolerance kidney transplantation Kidney transplantation noninherited maternal antigens |
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