| 西松烷型大环二萜类化合物研究进展 |
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| 引用本文： | 任晋,苏亚伦. 西松烷型大环二萜类化合物研究进展[J]. 中草药, 2014, 45(20): 2997-3008 |
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| 作者姓名： | 任晋 苏亚伦 |
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| 作者单位： | 中国医学科学院 北京协和医学院药物研究所, 北京 100050;中国医学科学院 北京协和医学院药物研究所, 北京 100050 |
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| 摘 要： | 西松烷型二萜类化合物是一大类结构新颖、特殊且具有重要生物活性的天然产物,目前分离得到的西松烷型二萜在结构上可分为异丙基型,五元、六元、七元、八元内酯环型,开环型,降碳型等类型,具有较好的细胞毒性和抗肿瘤活性。综述了2007年以来发现的193个新的西松烷类化合物的结构及生物活性,为进一步研究开发该类化合物提供依据。
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| 关 键 词： | 西松烷型二萜 天然产物 软珊瑚 细胞毒性 抗肿瘤 |
| 收稿时间： | 2014-05-13 |
Research progress on cembranoid type ring diterpenes |
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| REN Jin and SU Ya-lun. Research progress on cembranoid type ring diterpenes[J]. Chinese Traditional and Herbal Drugs, 2014, 45(20): 2997-3008 |
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| Authors: | REN Jin and SU Ya-lun |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Cembranoid type diterpenes are important natural products which have novel structures and remarkable bioactivities. Cembranoid type diterpenes obtained now included isopropyl type, five, six, seven, eight membered lactone ring, open ring, reducing carbon types, etc, with cytotoxicity and antitumor activity. This paper reviews the structures and bioactivities of 193 cembranoid diterpenes which have been discovered since 2007, providing the scientific evidence for reasonable exploitation and application of cembranoid diterpenes. |
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| Keywords: | cembranoid type diterpenes natural product soft coral cytotoxicity antitumor |
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