| 周围型肺癌CT征象与p53蛋白异常表达关系的研究 |
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| 引用本文： | 刘晓杰,张卫星,高桂芬. 周围型肺癌CT征象与p53蛋白异常表达关系的研究[J]. 中国肺癌杂志, 2002, 5(1): 18-20 |
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| 作者姓名： | 刘晓杰 张卫星 高桂芬 |
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| 作者单位： | 1. 150040,哈尔滨医科大学第三临床医学院影像诊断科
2. 150040,哈尔滨医科大学克山病研究所 |
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| 基金项目： | 黑龙江省卫生厅科研基金 (1999)资助 |
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| 摘 要： | 目的：探讨边缘型肺癌CT征象与肺癌组织中p53基因异常表达的关系。方法 临床选择肺占位性病变患者52例，行常规CT扫描。采用免疫组化法检测术后肺组织标本p53基因的表达。结果 p53蛋白阳性表达与肺癌分化程度、肺癌瘤体大小、肺癌瘤体形态、胸膜凹陷和淋巴结转移等CT征象有密切关系。结论 p53基因突变代表肺癌的生物学行为，并在一定程度上影响肺癌的形态学特征，与CT征象有密切关系。
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| 关 键 词： | 周围型肺癌 异常表达 p53蛋白 CT征象 |
| 修稿时间： | 2001-04-20 |
The relationship between the CT signs and p53 abnormal expression in peripheral lung cancer |
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| LIU Xiaojie ,ZHANG Weixing,GAO Guifen. Image Department,The Third Hospital,Harbin Medical University,Harbin,Heilongjiang ,P.R.China. The relationship between the CT signs and p53 abnormal expression in peripheral lung cancer[J]. Chinese journal of lung cancer, 2002, 5(1): 18-20 |
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| Authors: | LIU Xiaojie ZHANG Weixing GAO Guifen. Image Department The Third Hospital Harbin Medical University Harbin Heilongjiang P.R.China |
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| Affiliation: | LIU Xiaojie *,ZHANG Weixing,GAO Guifen. *Image Department,The Third Hospital,Harbin Medical University,Harbin,Heilongjiang 150040,P.R.China |
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| Abstract: | Objective To evaluate the relationship between the CT signs and p53 protein abnormal expression in peripheral lung cancer. Methods Fifty_two patients with pulmonary masses underwent CT scanning before operation. Immunohistochemistry was used to detect p53 protein expression in pulmonary specimens obtained by operation. Results There were significant differences among p53 protein expression and differentiation of lung cancer cell, size of the cancer, tumor appearance, pleura excavation and lymphatic metastasis. Conclusion p53 gene mutation indicates the biological behavior of lung cancer and might influence the morphological feature of lung cancer, which remarkably relates to CT signs of lung cancer. |
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| Keywords: | Lung neoplasms p53 protein CT appearance |
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