| 胃癌组织中hPOT1和p53表达及其临床意义 |
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| 引用本文： | 袁芳,蒋代富,李春鸣.胃癌组织中hPOT1和p53表达及其临床意义[J].山东医药,2011,51(7):4-6. |
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| 作者姓名： | 袁芳 蒋代富 李春鸣 |
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| 作者单位： | 1. 遵义医学院病理学教研室,贵州遵义,563003
2. 遵义医学院附属医院 |
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| 基金项目： | 贵州省优秀青年科技人才培养计划资助项目 |
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| 摘 要： | 目的探讨人端粒保护蛋白1（hPOT1）和p53在胃癌发生发展中的作用及机制。方法采用免疫组化SP法检测53份胃癌组织标本（观察组）及10份正常胃黏膜组织标本（对照组）hPOT1和p53蛋白表达;分析其与胃癌病理参数的关系。结果观察组hPOT1和p53蛋白阳性率均显著高于对照组P〈0.05;hPOT1表达与胃癌组织学分型、分化程度及浸润深度有关（P〈0.05）。p53表达与肿瘤浸润深度有关,P〈0.05;观察组hPOT1与p53蛋白表达呈正相关,P〈0.05。结论 hPOT1和p53参与了胃癌的发生、发展;联合检测hPOT1和p53蛋白表达有助于判断胃癌患者的预后。
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| 关 键 词： | 胃肿瘤 胃癌 端粒保护蛋白1 p53 免疫组织化学 |
Expression of hPOT1 and p53 in gastric cancer tissue and their clinical significance |
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| YUAN Fang,JIANG Dai-fu,LI Chun-ming.Expression of hPOT1 and p53 in gastric cancer tissue and their clinical significance[J].Shandong Medical Journal,2011,51(7):4-6. |
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| Authors: | YUAN Fang JIANG Dai-fu LI Chun-ming |
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| Institution: | YUAN Fang1,JIANG Dai-fu,LI Chun-ming(1 Department of Pathology,Zunyi Medical College,Zunyi 563003,P.R.China) |
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| Abstract: | ObjectiveTo investigate the roles and mechanism of human protection of telomeres(hPOT1) and p53 in the occurrence and development of gastric cancer.MethodsThe expression of hPOT1 and p53 protein were detected by SP immunohistochemical method in 53 gastric cancer specimens(observed group) and 10 normal gastric mucosa(control group);the correlation between the indexes and pathological parameters were analyzed.ResultsThe positive rate of hPOT1 and p53 protein in the observed group were both significantly highe... |
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| Keywords: | p53 |
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