| ATG16L1基因多态性与广西壮族人群炎症性肠病的关系 |
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| 引用本文： | 陈兰,吕小平,詹灵凌,唐星火. ATG16L1基因多态性与广西壮族人群炎症性肠病的关系[J]. 山东医药, 2011, 51(13): 10-12 |
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| 作者姓名： | 陈兰 吕小平 詹灵凌 唐星火 |
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| 作者单位： | 1. 广西医科大学第一附属医院西院,南宁,530021
2. 广西医科大学第一附属医院临床医学实验部 |
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| 基金项目： | 广西科学基金资助项目，广西研究生教育创新项目 |
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| 摘 要： | 目的研究ATG16L1基因单核苷酸多态性（SNP）位点rs2241880与中国广西壮族炎症性肠病（IBD）易感性的关系。方法分别收集146例中国广西IBD患者[其中溃疡性结肠炎（UC）86例，克罗恩病（CD）60例]与164例正常对照者的肠黏膜组织，用酚一氯仿法提取DNA，采用聚合酶链反应（PCR）扩增ATG16L1基因，PCR产物片段直接进行DNA测序分析，结果在Genbank基因库上进行序列比较。结果UC、CD患者与正常对照组之间ATG16L1基因SNP位点rs2241880的等位基因多态性无统计学差异（P〉0．05）。结论ATG16L1基因SNP位点rs2241880与广西壮族IBD患者的易感性无关。
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| 关 键 词： | 克罗恩病 结肠炎，溃疡性 炎症性肠病 ATG16L1基因 多态性，单核苷酸 |
Relationship of ATG16L1 gene polymorphisms with inflammatory bowel disease in zhuang population of Guangxi province |
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| CHEN Lan,LV Xiao-ping,ZHAN Ling-ling,TANG Xing-huo. Relationship of ATG16L1 gene polymorphisms with inflammatory bowel disease in zhuang population of Guangxi province[J]. Shandong Medical Journal, 2011, 51(13): 10-12 |
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| Authors: | CHEN Lan LV Xiao-ping ZHAN Ling-ling TANG Xing-huo |
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| Affiliation: | CHEN Lan1,LV Xiao-ping,ZHAN Ling-ling,TANG Xing-huo (1 Western Hospital of First Affiliated Hospital of Guangxi Medical University,Nanning 530021,P.R.China) |
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| Abstract: | Objective To explore the correlation between susceptibility to inflammatory bowel disease(IBD)in Chinese zhuang population of Guangxi province and ATG16L1 gene single nucleotide polymorphisms(SNP),rs2241880.Methods The Intestinal tissue of 146 patients of IBD and 164 healthy people were collected.Genomic DNA was extracted from intestinal tissueusing with phenol chloroform methodology.Polymerase chain reaction was used to amplify the ATG16L1 gene,and products were sequenced using the sequencer.The sequenced ... |
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| Keywords: | Crohn' s disease colitis ulcerative inflammatory bowel disease ATG16L1 gene polymorphism single nucleotide |
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