| 鼻咽癌组织中P120ctn、VEGF-C的表达及临床意义 |
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| 引用本文： | 欧海玲,刘姗姗,姚平,王进声,张锡流.鼻咽癌组织中P120ctn、VEGF-C的表达及临床意义[J].山东医药,2011,51(11):10-11. |
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| 作者姓名： | 欧海玲 刘姗姗 姚平 王进声 张锡流 |
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| 作者单位： | 广西中医学院,南宁,53001 |
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| 基金项目： | 广西自然科学基金资助项目，广西壮族自治区卫生厅自筹经费科研课题，广西中医学院重点课题资助项目 |
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| 摘 要： | 目的探讨链蛋白P120（P120ctn）、血管内皮生长因子-C（VEGF-C）在鼻咽癌组织中的表达及意义。方法采用免疫组化二步法检测56份鼻咽癌（鼻咽癌组）和15份正常鼻咽黏膜（正常组）组织中P120ctn和VEGF-C的表达情况,并分析两者间及与鼻咽癌临床病理特征的关系。结果鼻咽癌组和正常组P120ctn异常表达率分别为67.86%6、.67%,VEGF-C阳性表达率分别为83.92%、26.6%,两两比较P均〈0.05;P120ctn异常表达与鼻咽癌病理分型、TNM分期、颈部淋巴结转移相关,VEGF-C阳性表达与鼻咽癌TNM分期、颈部淋巴结转移相关;鼻咽癌组织中P120ctn与VEGF-C表达呈正相关。结论鼻咽癌的发生发展过程中常发生P120ctn和VEGF-C的表达异常,与肿瘤的浸润、转移有关,可作为判断鼻咽癌生物学特征和预后的重要指标。
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| 关 键 词： | 耳鼻咽喉肿瘤 链蛋白P120 血管内皮生长因子-C 临床病理特征 |
Expression and clinical significance of P120ctn,VEGF-C in human nasopharyngeal carcinoma |
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| OU Hai-ling,LIU Shan-shan,YAO Ping,WANG Jin-sheng,ZHANG Xi-liu.Expression and clinical significance of P120ctn,VEGF-C in human nasopharyngeal carcinoma[J].Shandong Medical Journal,2011,51(11):10-11. |
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| Authors: | OU Hai-ling LIU Shan-shan YAO Ping WANG Jin-sheng ZHANG Xi-liu |
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| Institution: | OU Hai-ling,LIU Shan-shan,YAO Ping,WANG Jin-sheng,ZHANG Xi-liu(Guangxi Traditional Chinese Medical University,Nanning 530001,P.R.China) |
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| Abstract: | Objective To investigate the expression and significance of P120 catenin(P120ctn),vascular endothelial growth factor-C(VEGF-C) in human nasopharyngeal carcinoma.Methods Using immuno-histochemical technique to examine the expression of P120ctn,VEGF-C in 56 nasopharyngeal carcinoma cases(nasopharyngeal carcinoma group)and 15 normal mucous membrane of nasopharynx cases(normal group),and the relations between P120ctn,VEGF-C and clinicopathological features were analyzed.Results P120ctn abnormal rate of the naso... |
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| Keywords: | neoplasm P120 catenin vascular endothelial growth factor-C clinicopathological features |
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