鼻息肉上皮细胞中Fas、FasL和Bcl-2的表达及其意义

其其发病学意义。方法:用免疫组化染色法检测鼻息肉组(29例)和下鼻甲组(11例)上皮细胞Fas、FasL、Bcl-2基因蛋白的表达。结果:鼻息肉组上皮细胞Fas、FasL和Bcl-2阳性细胞指数(PIFas、PIFasL、PIBcl-2)均大于下鼻甲组(P<0.01),PIBcl-2/PIFas也大于下鼻甲组(P<0.01),但鼻息肉组PIFasL/PIFas与下鼻甲组比无统计学意义;鼻息肉组PIFasL/PIFas和PIBcl-2/PIFas均大于1(理论值,P<0.05)。结论:Bcl-2介导的抑制细胞凋亡机制和FasL介导的细胞免疫逃逸机制可能对Fas/FasL系统介导的细胞凋亡产生部分抑制作用,有可能是鼻息肉上皮细胞增殖和细胞凋亡平衡失调的根本原因。

The Expression and Significance of Fas, FasL and Bcl-2 in Epithelial Cells of Nasal Polyps

Objectiv:To explore the expression and its pathogenic significance of apoptosis-associated proteins(Fas,FasL and Bcl-2)in epithelial cells of nasal polyps.Methods:The protein expressions of Fas,FasL and Bcl-2 of epithelial cells in the nasal polyps group(29 cases)and in the inferior turbinate group(11 cases)were detected by immunohistochemical staining.Results:PIFas,PIFasL and PIBcl-2 of epithelial cells in the nasal polyps group were higher than those of epithelial cells in the inferior turbinate group(P<0.01).PIBcl-2/PIFas of epithelial cells in the nasal polyps group was higher than that of epithelial cells in the inferior turbinate group(P<0.01),however,PIFasL/PIFas in the nasal polyps group was no significant difference compared with the inferior turbinate.PIFasL/PIBcl-2 of epithelial cells in the nasal polyps group was higher than PIFas(P<0.05).Conclusion:Both Bcl-2 mediated apoptosis inhibition mechanism and FasL mediated cell immune escape mechanism may partly inhibite Fas/FasL system mediated cell apoptosis in epithelia of nasal polyps.This might be the ultimate cause leading to imbalance between proliferation and apoptosis on epithelia in nasal polyps.