| HPLC法检查卡络磺钠葡萄糖注射液中5-羟甲基糠醛限量 |
| |
| 引用本文： | 周光树,黄顺旺.HPLC法检查卡络磺钠葡萄糖注射液中5-羟甲基糠醛限量[J].安徽医药,2009,13(8):888-889. |
| |
| 作者姓名： | 周光树 黄顺旺 |
| |
| 作者单位： | 安徽省立友谊医院药剂科,安徽,合肥,230011;安徽省药物研究所,安徽,合肥,230022 |
| |
| 摘 要： | 目的建立高效液相色谱法检查卡络磺钠葡萄糖注射液中5-羟甲基糠醛（5-HMT）限量。方法采用色谱柱：D iamonsil-C18柱（250 mm×4.6 mm,5μm）;0.12%磷酸二氢铵溶液-乙腈（91∶9）为流动相;检测波长为284 nm。结果5-HMT浓度在1.036～5.180 mg.L-1范围内有良好的线性关系（r=0.9999）,平均回收率为98.86%,RSD为1.05%（n=9）。结论此法简便、准确,适用于卡络磺钠葡萄糖注射液中5-HMT的限量测定。
|
| 关 键 词： | 卡络磺钠葡萄糖注射液 5-HMT HPLC 限量测定 |
Limit of 5-hidroxymethy furfural in carbazochrome sodium sulfonate and glucose injection by HPLC |
| |
| ZHOU Guang-shu,HUANG Shun-wang.Limit of 5-hidroxymethy furfural in carbazochrome sodium sulfonate and glucose injection by HPLC[J].Anhui Medical and Pharmaceutical Journal,2009,13(8):888-889. |
| |
| Authors: | ZHOU Guang-shu HUANG Shun-wang |
| |
| Institution: | ZHOU Guang-shu1,HUANG Shun-wang2 (1.Department of Pharmacy,Anhui Provincial Friendship Hospital,Hefei 230011,2.Anhui Institute of Materia Medica,Hefei 230022) |
| |
| Abstract: | Aim To establish an HPLC method for assay of 5-HMT in carbazochrome sodium sulfonate and glucose injection.Methods The assay was performed on a Diamonsil-C18 column（4.6 mm×250 mm,5 μm）.The mobile phase was composed of 0.12% NH4H2PO4-acetonitrile（91∶9）.The detection wavelength was 284 nm.Results 5-HMT showed a good linear（r=0.9999）in the range between 1.036 and 5.180 mg·L-1.The average recovery was 98.86%,with an RSD of 1.05%.Conclusion The method is simple and accurate for the limit of 5-HMT in carbazochrome sodium sulfonate and glucose injection. |
| |
| Keywords: | 5-HMT HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
