2型糖尿病患者活化血小板糖基化复合物活性与脂代谢异常的相关性

探讨2型糖尿病患者血小板活化与脂代谢异常的关系.将120例2型糖尿病患者按有无脂代谢异常分为有脂代谢异常组(n=62)和无脂代谢异常组(n=58),并选择25例正常者作对照.应用流式细胞仪分别测定各组的活化血小板糖基化复合物活性,比较两组糖尿病患者活化血小板糖基化复合物活性的差异,并分析其与甘油三酯、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇水平的相关性.结果发现,两组糖尿病患者的活化血小板糖基化复合物活性均明显高于正常对照组,且有脂代谢异常的糖尿病组活化血小板糖基化复合物活性高于无脂代谢异常组,低密度脂蛋白胆固醇水平与活化血小板糖基化复合物活性显著正相关(r=0.64, P<0.05).结果提示, 2型糖尿病患者脂代谢异常是导致血小板活化水平增高的重要因素.

Glycopropean Complex of Activated Platelet Level and Its Association with Lipid Metabolic Disturbance in Cases of Type 2 Diabetes Mellitus

Aim To examine the relationship between glycopropean complex of activated platelet (PAC-1) and lipid metabolic disturbance in cases of type 2 diabetes mellitus (DM). Methods One hundred and twenty two patients with DM (type 2) were divided into lipid metabolic disturbance group (62 cases) and normal lipid metabolism group (58 cases). 25 normals were selected as the control. Flow-cytometry was used to detect the PAC-1 level and therefore the deference between the two groups was analysed. The correlation between triglyceride (TG), high density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDLC) and PAC-1 was also evaluated. Results The PAC-1 level in type 2 DM cases was higher than that in control subjects. It was also markedly higher in abnormal lipid metabolic cases than that in normal lipid metabolic cases. LDLC correlated positively with PAC-1 (r=0.64, P<0.05). Conclusion Abnormal lipid metabolism is the main factor resulting in a high PAC-1 level.