| 美仑孕酮醋酸酯的合成新工艺 |
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| 引用本文： | 寻国良,廖清江. 美仑孕酮醋酸酯的合成新工艺[J]. 中国药物化学杂志, 2005, 15(3): 170-172 |
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| 作者姓名： | 寻国良 廖清江 |
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| 作者单位： | 中国药科大学,药物化学教研室,江苏,南京,210009 |
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| 摘 要： | 目的合成美仑孕酮醋酸酯.方法以双烯醇酮醋酸酯为原料经过环合、热解、环氧化、开环氧环、破环氧环、水解、氧化、Mannich反应、消除、转位等9步反应合成美仑孕酮醋酸酯.结果与结论目标化合物经红外光谱、核磁共振氢谱、质谱及元素分析确证其化学结构.
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| 关 键 词： | 药物化学 工艺改进 化学合成 美仑孕酮醋酸酯 |
| 文章编号： | 1005-0108(2005)03-0170-03 |
New synthetic route of melengestrol acetate |
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| XUN Guo-liang,LIAO Qing-jiang. New synthetic route of melengestrol acetate[J]. Chinese Journal of Medicinal Chemistry, 2005, 15(3): 170-172 |
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| Authors: | XUN Guo-liang LIAO Qing-jiang |
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| Abstract: | Aim To establish a new approach for the synthesis of melengestrol acetate.Method Target compound was synthesized by using 3-acetoxy-5,16-pregnadien-20-one as starting material,via a nine steps process (including cyclization,thermolysis,epoxidation,epoxy-ring opening,hydrolysis,oxidation,Mannich reaction,elimination,isomerization).Results and conclusion The chemical structure of the target compound is confirmed by IR, 1H-NMR,MS and elemental analysis.A convenient synthetic route is found. |
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| Keywords: | medicinal chemistry process improvement chemical synthesis melengestrol acetate |
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